Stereochemical effects of 11-OH-Δ 8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor

@article{Howlett1990StereochemicalEO,
  title={Stereochemical effects of 11-OH-$\Delta$
 8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor},
  author={Allyn C. Howlett and T. M. Champion and Gerald H. Wilken and Raphael Mechoulam},
  journal={Neuropharmacology},
  year={1990},
  volume={29},
  pages={161-165}
}
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The binding of [3H]-5'-trimethylammonium delta 8-tetrahydrocannabinol (THC) [( 3H]TMA) to rat neuronal membranes was studied and it was found that several nonpsychotropic cannabinoids are active at the binding site.
Comparative Pharmacology of Δ9-Tetrahydrocannabinol and its Metabolite, 11-OH-Δ9-Tetrahydrocannabinol
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It is suggested that in man, A9-THC, the active constituent in marihuana, is converted to 11-OHY9-Tetrahydrocannabinol, which is in part responsible for the psychologic effects.
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TLDR
It is postulated that the receptor that is associated with the regulation of adenylate cyclase in vitro may be the same receptor as that mediating analgesia in vivo, and a conceptualization of the cannabinoid analgetic receptor is presented.
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TLDR
Inhibition of adenylate cyclase was specific for psychoactive cannabinoids, since cannabinol and cannabidiol produced minimal or no response, and was also stereoselective, since dextronantradol did not produce the response.
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