Stereochemical analysis of leubethanol, an anti-TB-active serrulatane, from Leucophyllum frutescens.

  title={Stereochemical analysis of leubethanol, an anti-TB-active serrulatane, from Leucophyllum frutescens.},
  author={Gloria Mar{\'i}a Molina-Salinas and Ver{\'o}nica M Rivas-Galindo and Salvador L Said-Fern{\'a}ndez and David C Lankin and Marcelo Andr{\'e}s Mu{\~n}oz and Pedro Joseph-Nathan and Guido F Pauli and Noem{\'i} Waksman},
  journal={Journal of natural products},
  volume={74 9},
Bioactivity-guided fractionation of the methanolic root bark extract of Leucophyllum frutescens led to the identification of leubethanol (1), a new serrulatane-type diterpene with activity against both multi-drug-resistant and drug-sensitive strains of virulent Mycobacterium tuberculosis. Leubethanol (1) was identified by 1D/2D NMR data, as a serrulatane closely related to erogorgiane (2), and exhibited anti-TB activity with minimum inhibitory concentrations in the range 6.25-12.50 μg/mL… CONTINUE READING
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