Stereo-selective neuroprotection against stroke with vitamin A derivatives.

  title={Stereo-selective neuroprotection against stroke with vitamin A derivatives.},
  author={Yu Sato and Robert Meller and Tao Yang and Waro Taki and Roger Simon},
  journal={Brain research},
In this study we evaluated the neuroprotective potential of vitamin A (all-trans retinol), and its geometric isomers, all-trans retinoic acid and 9-cis retinoic acid, in a focal model of ischemia. A 60 minute middle cerebral artery occlusion in C57 mice resulted in over 50% hemispheric infarction. Vitamin A (retinol) and its derivatives were administered as two i.p. injections immediately prior to and following ischemia. A reduction in infarct volume was observed with all-trans retinol, in a… CONTINUE READING
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