Stepwise transfer of tRNA through the double membrane of Leishmania mitochondria.

@article{Mukherjee1999StepwiseTO,
  title={Stepwise transfer of tRNA through the double membrane of Leishmania mitochondria.},
  author={Sambudho Mukherjee and Suvendra N Bhattacharyya and Samit Adhya},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 44},
  pages={31249-55}
}
Import of tRNA into Leishmania mitochondria involves transfer through a double membrane barrier. To examine whether specific sorting mechanisms for individual tRNAs direct them to different mitochondrial compartments, the distribution of tRNA transcripts, internalized in vitro, was examined by suborganellar fractionation. Significant amounts of tRNA(Tyr) were localized in the matrix and on the outer face of the inner mitochondrial membrane. With time, the matrix:membrane ratio increased… CONTINUE READING

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