Stepwise mutation model and distribution of allelic frequencies in a finite population.

@article{Kimura1978StepwiseMM,
  title={Stepwise mutation model and distribution of allelic frequencies in a finite population.},
  author={Motoo Kimura and Tomoko Ohta},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1978},
  volume={75 6},
  pages={2868-72}
}
A mathematical theory is developed that enables us to derive a formula for the equilibrium distribution of allelic frequencies in a finite population when selectively neutral alleles are produced in stepwise fashion (stepwise mutation model). It is shown that the stepwise mutation model has a remarkable property that distinguishes it from the conventional infinite allele model (Kimura-Crow model): as the population size increases indefinitely while the product of the effective population size… CONTINUE READING
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