Stepwise folding of an autotransporter passenger domain is not essential for its secretion.

Abstract

Autotransporters are a superfamily of virulence proteins produced by Gram-negative bacteria. They consist of an N-terminal β-helical domain ("passenger domain") that is secreted into the extracellular space and a C-terminal β-barrel domain ("β-domain") that anchors the protein to the outer membrane. Because the periplasm lacks ATP, vectorial folding of the… (More)
DOI: 10.1074/jbc.M113.515635

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Cite this paper

@article{Kangethe2013StepwiseFO, title={Stepwise folding of an autotransporter passenger domain is not essential for its secretion.}, author={Wanyoike Kang'ethe and Harris D Bernstein}, journal={The Journal of biological chemistry}, year={2013}, volume={288 49}, pages={35028-38} }