Stepwise differentiation of human embryonic stem cells promotes tendon regeneration by secreting fetal tendon matrix and differentiation factors.

@article{Chen2009StepwiseDO,
  title={Stepwise differentiation of human embryonic stem cells promotes tendon regeneration by secreting fetal tendon matrix and differentiation factors.},
  author={Xiao Chen and Xing-Hui Song and Zi Yin and Xiao-hui Zou and Li Wang and Hu Hu and Tong Cao and Minghao Zheng and Hongwei Ouyang},
  journal={Stem cells},
  year={2009},
  volume={27 6},
  pages={1276-87}
}
Human embryonic stem cells (hESCs) are ideal seed cells for tissue regeneration, but no research has yet been reported concerning their potential for tendon regeneration. This study investigated the strategy and efficacy of using hESCs for tendon regeneration as well as the mechanism involved. hESCs were first induced to differentiate into mesenchymal stem cells (MSCs), which had the potential to differentiate into the three mesenchymal lineages and were positive for MSC surface markers. hESC… CONTINUE READING

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