Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs

  title={Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs},
  author={Kouji Hirota and Tomoichiro Miyoshi and Kazuto Kugou and Charles S Hoffman and Takehiko Shibata and Kunihiro Ohta},
Recent transcriptome analyses using high-density tiling arrays and data from large-scale analyses of full-length complementary DNA libraries by the FANTOM3 consortium demonstrate that many transcripts are non-coding RNAs (ncRNAs). These transcriptome analyses indicate that many of the non-coding regions, previously thought to be functionally inert, are actually transcriptionally active regions with various features. Furthermore, most relatively large (∼several kilobases) polyadenylated… 

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