Stepwise arteriovenous fate acquisition during mammalian vasculogenesis.

  title={Stepwise arteriovenous fate acquisition during mammalian vasculogenesis.},
  author={Diana C. Chong and Yeon Koo and Ke Xu and Stephen Fu and Ondine Cleaver},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  volume={240 9},
Arteriovenous (AV) differentiation is a critical step during blood vessel formation and stabilization. Defects in arterial or venous fate lead to inappropriate fusion of vessels, resulting in damaging arteriovenous shunts. While many studies have unraveled the molecular underpinnings that drive AV fate, surprisingly, the spatiotemporal emergence of arteries and veins in mammalian embryos remains unknown. Here, we examine artery and vein specification and differentiation during vasculogenesis… CONTINUE READING

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