Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

@article{Knowland2014StepwiseRO,
  title={Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke},
  author={Daniel Knowland and Ahmet Araç and Kohei J. Sekiguchi and Martin Hsu and Sarah E. Lutz and John Perrino and G K Steinberg and Ben A Barres and Axel Nimmerjahn and Dritan Agalliu},
  journal={Neuron},
  year={2014},
  volume={82},
  pages={603-617}
}
Brain endothelial cells form a paracellular and transcellular barrier to many blood-borne solutes via tight junctions (TJs) and scarce endocytotic vesicles. The blood-brain barrier (BBB) plays a pivotal role in the healthy and diseased CNS. BBB damage after ischemic stroke contributes to increased mortality, yet the contributions of paracellular and transcellular mechanisms to this process in vivo are unknown. We have created a transgenic mouse strain whose endothelial TJs are labeled with eGFP… CONTINUE READING