Stepwise Approach toward First Generation Nonenzymatic Hydrolases.


The synthesis and reactivity study of a first generation serine protease mimic is described. Central in the design stands the possibility of stabilization of the transition state by an amino triol such as 8t. En route to 8t, a series of amino alcohols (4-8) was obtained, the reactivity of which was studied toward esterification by acetylimidazole (AcIm) and… (More)


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@article{Madder1998StepwiseAT, title={Stepwise Approach toward First Generation Nonenzymatic Hydrolases.}, author={Annemieke Madder and Pierre J. De Clercq and J. P. Declercq}, journal={The Journal of organic chemistry}, year={1998}, volume={63 8}, pages={2548-2559} }