Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling.

@article{Crompton2013StepwiseND,
  title={Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling.},
  author={Lucy A. Crompton and Meg L Byrne and Hannah Taylor and Talitha L. Kerrigan and Gilles Bru-Mercier and Jennifer L Badger and Peter A. Barbuti and Jihoon Jo and Sue J. Tyler and Shelley J. Allen and Tilo Kunath and Kwangwook Cho and Maeve A Caldwell},
  journal={Stem cell research},
  year={2013},
  volume={11 3},
  pages={1206-21}
}
Basal forebrain cholinergic neurons (bfCNs) which provide innervation to the hippocampus and cortex, are required for memory and learning, and are primarily affected in Alzheimer's Disease (AD), resulting in related cognitive decline. Therefore generation of a source of bfCNs from human pluripotent stem cells (hPSCs) is crucial for in vitro disease modeling and development of novel AD therapies. In addition, for the advancement of regenerative approaches there is a requirement for an accurate… CONTINUE READING
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