Steps towards the synthetic biology of polyketide biosynthesis

@inproceedings{Cummings2014StepsTT,
  title={Steps towards the synthetic biology of polyketide biosynthesis},
  author={Matthew Cummings and Rainer Breitling and Eriko Takano},
  booktitle={FEMS microbiology letters},
  year={2014}
}
Nature is providing a bountiful pool of valuable secondary metabolites, many of which possess therapeutic properties. However, the discovery of new bioactive secondary metabolites is slowing down, at a time when the rise of multidrug-resistant pathogens and the realization of acute and long-term side effects of widely used drugs lead to an urgent need for new therapeutic agents. Approaches such as synthetic biology are promising to deliver a much-needed boost to secondary metabolite drug… CONTINUE READING
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