Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer's disease.

@article{Jack2011StepsTS,
  title={Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer's disease.},
  author={Clifford R. Jack and Frederik Barkhof and Matt A. Bernstein and Marc Cantillon and Patricia E. Cole and Charles DeCarli and Bruno Dubois and Simon Duchesne and Nick C. Fox and Giovanni B. Frisoni and Harald Hampel and Derek L. G. Hill and Keith Johnson and Jean-Francois Mangin and Philip Scheltens and Adam J Schwarz and Reisa Sperling and Joyce Suhy and Paul M. Thompson and Michael Weiner and Norman L. Foster},
  journal={Alzheimer's & dementia : the journal of the Alzheimer's Association},
  year={2011},
  volume={7 4},
  pages={474-485.e4}
}
BACKGROUND The promise of Alzheimer's disease biomarkers has led to their incorporation in new diagnostic criteria and in therapeutic trials; however, significant barriers exist to widespread use. Chief among these is the lack of internationally accepted standards for quantitative metrics. Hippocampal volumetry is the most widely studied quantitative magnetic resonance imaging measure in Alzheimer's disease and thus represents the most rational target for an initial effort at standardization… CONTINUE READING
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