Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation.

@article{Hoppe2002StepsIA,
  title={Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation.},
  author={Georg J Hoppe and Jason C. Tanny and Adam D Rudner and Scott A. Gerber and Sherwin Danaie and Steven P Gygi and Danesh Moazed},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 12},
  pages={4167-80}
}
Transcriptional silencing at the budding yeast silent mating type (HM) loci and telomeric DNA regions requires Sir2, a conserved NAD-dependent histone deacetylase, Sir3, Sir4, histones H3 and H4, and several DNA-binding proteins. Silencing at the yeast ribosomal DNA (rDNA) repeats requires a complex containing Sir2, Net1, and Cdc14. Here we show that the native Sir2/Sir4 complex is composed solely of Sir2 and Sir4 and that native Sir3 is not associated with other proteins. We further show that… CONTINUE READING

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