Stepped wedge designs could reduce the required sample size in cluster randomized trials.

@article{Woertman2013SteppedWD,
  title={Stepped wedge designs could reduce the required sample size in cluster randomized trials.},
  author={Willem H. Woertman and Esther de Hoop and Mirjam Moerbeek and Sytse U. Zuidema and Debby Lydia Gerritsen and Steven Teerenstra},
  journal={Journal of clinical epidemiology},
  year={2013},
  volume={66 7},
  pages={752-8}
}
OBJECTIVE The stepped wedge design is increasingly being used in cluster randomized trials (CRTs). However, there is not much information available about the design and analysis strategies for these kinds of trials. Approaches to sample size and power calculations have been provided, but a simple sample size formula is lacking. Therefore, our aim is to provide a sample size formula for cluster randomized stepped wedge designs. STUDY DESIGN AND SETTING We derived a design effect (sample size… CONTINUE READING
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