Stepped changes of monovalent ligand-binding force during ligand-induced clustering of integrin alphaIIB beta3.

Abstract

Recent evidence demonstrated that conformational changes of the integrin during receptor activation affected its binding to extracellular matrix; however, experimental assessment of ligand-receptor binding following the initial molecular interaction has rarely been carried out at a single-molecule resolution. In the present study, laser tweezers were used… (More)

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@article{Hsieh2006SteppedCO, title={Stepped changes of monovalent ligand-binding force during ligand-induced clustering of integrin alphaIIB beta3.}, author={Chia-Fen Hsieh and Bo-Jui Chang and Chyi-Huey Pai and Hsuan-Yi Chen and Jin-Wu Tsai and Yung-Hsiang Yi and Yi-Ting Chiang and Da-Wei Wang and Sien Chi and Long Hsu and Chi-Hung Lin}, journal={The Journal of biological chemistry}, year={2006}, volume={281 35}, pages={25466-74} }