Stephen C. Woods: A precocious scientist

  title={Stephen C. Woods: A precocious scientist},
  author={GERARD P. Smith},
  journal={Physiology \& Behavior},
To investigate the early scientific development of Steve Woods, I reviewed his research during the first decade after he received his doctoral degree in 1970. The main parts of his research program were conditioned insulin secretion and hypoglycemia, Pavlovian conditioning of insulin secretion before a scheduled access to food, and basal insulin as a negative-feedback signal from fat mass to the brain. These topics were pursued with experimental ingenuity; the resulting publications were… Expand
3 Citations
From conditioned hypoglycemia to obesity: Following the data
  • S. Woods
  • Psychology, Medicine
  • Physiology & Behavior
  • 2013
This article summarizes how the underlying physiology of conditioned insulin secretion and conditioned hypoglycemia was understood, and the entry of insulin into the brain, the existence of insulin receptors in certain brain areas, and neural reflexes that project to insulin-secreting B-cells in the pancreas were tackled. Expand
Homeostastic and non-homeostatic functions of melanocortin-3 receptors in the control of energy balance and metabolism
The data suggest that the central nervous melanocortin system is a point convergence in the control of energy balance and the expression of rhythms anticipating nutrient intake. Expand
The final problem
  • S. Woods
  • Medicine, Psychology
  • Physiology & Behavior
  • 2011


Handbook of Physiology.
This is the first volume of the proposed many-sectioned "Handbook" in which the American Physiological Society intends to present comprehensively the entire field of physiology. The scope and depthExpand
Homeostasis: Beyond Curt Richter
This work believes that prevailing sentiment favors a broader view in which organisms integrate anticipatory pre-emptive control over regulated variables whenever possible. Expand
Classically Conditioned Changes of Blood Glucose Level
Instances of more naturally occurring changes of glucose levels, which appear to be under the control of the nervous system and to be conditionable, are discussed and a model that accounts for the observed responses is presented. Expand
The central nervous system, pancreatic hormones, feeding, and obesity.
The innervation of the islets, coupled with the effects upon insulin and glucagon secretion of stimulation of the nerves to the pancreas, suggests that the central nervous system normally exerts an influence upon the islet function. Expand
Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
Additional evidence is presented by showing that in baboons the infusion of exogenous insulin into the CSF elicits a reliable and predictable decrease in food intake and body weight. Expand
Growth hormone and insulin levels in weanling rats with ventromedial hypothalamic lesions.
It is suggested that the ventromedial nucleus exerts a significant control over growth hormone secretion, presumably through a growth hormone releasing factor, and that its destruction results in growth impairment secondary to a deficiency in growth hormone secre... Expand
Homeostasis and drinking
Drinking and thirst-motivated behaviour have traditionally been explained in terms of the rather simple concept of homeostasis. A homeostatic mechanism readily accounts for responses to acute changesExpand
Conditioned insulin secretion and meal feeding in rats.
It is concluded that the hyperinsulinemia of meal-fed rats associated with their feeding time is a learned response and could become associated with arbitrary stimuli always associated with eating for meal- fed rats. Expand
Meal-anticipatory glucagon-like peptide-1 secretion in rats.
Findings document for the first time a cephalic increase of plasma GLP-1 and suggest that it functions to facilitate consumption of a large meal. Expand
Neuropeptide Y prepares rats for scheduled feeding.
NPY plays a role in mediating conditionable food-anticipatory responses that help to cope with the effects of large caloric loads, and timed daily NPY injections may be expected to condition meal-anticipated responses that facilitate ingestion. Expand