Stent-based delivery of decoy oligodeoxynucleotides against activator protein-1 binding site decreased restenosis in rabbits.

@article{Lin2013StentbasedDO,
  title={Stent-based delivery of decoy oligodeoxynucleotides against activator protein-1 binding site decreased restenosis in rabbits.},
  author={Kaimin Lin and Ziwen Zhao and Lianglong Chen},
  journal={Die Pharmazie},
  year={2013},
  volume={68 8},
  pages={661-7}
}
The application of drug eluting stents (DES) significantly reduced the rate of restenosis but is associated with increased risk of late stage thrombosis. Thus, development of more effective and safer drugs for in stent delivery to inhibit restenosis is of great clinical interest. Decoy oligodeoxynucleotides against activator protein-1 (AP-1) binding site (dec-ODN) delivered with one time infusion or transfer have been shown to effectively inhibit neointimal proliferation and thickening. In this… CONTINUE READING