Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

@article{Brooke2012StenotrophomonasMA,
  title={Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen},
  author={Joanna S. Brooke},
  journal={Clinical Microbiology Reviews},
  year={2012},
  volume={25},
  pages={2 - 41}
}
  • J. Brooke
  • Published 1 January 2012
  • Biology, Medicine
  • Clinical Microbiology Reviews
SUMMARY Stenotrophomonas maltophilia is an emerging multidrug-resistant global opportunistic pathogen. The increasing incidence of nosocomial and community-acquired S. maltophilia infections is of particular concern for immunocompromised individuals, as this bacterial pathogen is associated with a significant fatality/case ratio. S. maltophilia is an environmental bacterium found in aqueous habitats, including plant rhizospheres, animals, foods, and water sources. Infections of S. maltophilia… 
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Update on infections caused by Stenotrophomonas maltophilia with particular attention to resistance mechanisms and therapeutic options

A synthesis of information on current global trends in S. maltophilia pathogenicity as well as updated information on the molecular mechanisms contributing to its resistance to an array of antimicrobial agents is provided.

Stenotrophomonas maltophilia – a low-grade pathogen with numerous virulence factors

The present review summarizes the literature data regarding extracellular and cell-associated virulence factors of S. maltophilia and considers the basic characteristics of biofilm formation.

Elucidating pathogenic determinants in stenotrophomonas maltophilia pathogenesis

Clinical isolates of S. maltophila are a reservoir for pathogenic potential enzymes, according to an array of extracellular enzymes in S.maltophilia, which suggests that the bacterium is a potentially dangerous pathogen.

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Cooperativity between Stenotrophomonas maltophilia and Pseudomonas aeruginosa during Polymicrobial Airway Infections

The results of this study indicate that S. maltophilia transiently colonizes the lung accompanied by significant weight loss and immune cell infiltration and the expression of early inflammatory markers, including interleukin 6 (IL-6), IL-1α, and tumor necrosis factor alpha (TNF-α) and these organisms colocalize in the lung during dual-species infection.

A Stenotrophomonas maltophilia Strain Evades a Major Caenorhabditis elegans Defense Pathway

A novel host-pathogen interaction between C. elegans and S. maltophilia is discovered and a new animal model is established with which to study the mode of action of this emerging nosocomial pathogen.

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Investigating the antibiotic susceptibility patterns and risk factors contributing to S. maltophilia infections found it to be an important nosocomial opportunistic pathogen and minocycline and ceftazidime were found to be the most and least susceptible drugs.

New strategies against Stenotrophomonas maltophilia: a serious worldwide intrinsically drug-resistant opportunistic pathogen

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This editorial reports on newer drugs and antimicrobial strategies and their potential for use in treatment of S. maltophilia infections, the development of new technologies to detect this organism, and identifies strategies currently in use to reduce transmission of this pathogen.

An In-Depth Analysis of Stenotrophomonas maltophilia: A Multi-Drug ResistantPathogen

Stenotrophomonas maltophilia relates to an aerobic, gram-negative, motile, as well as non-fermentative bacillus widely considered an opportunistic pathogen. In most cases, it leads to infection in…

Antimicrobial Susceptibility of Stenotrophomonas maltophilia Clinical Isolates from Blood Samples in Iran

increasing rate of immunocompromised patients, prolonged consumption of antibiotics in hospitalized patients and some genetic disorders like cystic fibrosis make it essential to monitor S. maltophilia drug resistance status.
...

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