Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

  title={Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen},
  author={Joanna S. Brooke},
  journal={Clinical Microbiology Reviews},
  pages={2 - 41}
  • J. Brooke
  • Published 1 January 2012
  • Biology, Medicine
  • Clinical Microbiology Reviews
SUMMARY Stenotrophomonas maltophilia is an emerging multidrug-resistant global opportunistic pathogen. The increasing incidence of nosocomial and community-acquired S. maltophilia infections is of particular concern for immunocompromised individuals, as this bacterial pathogen is associated with a significant fatality/case ratio. S. maltophilia is an environmental bacterium found in aqueous habitats, including plant rhizospheres, animals, foods, and water sources. Infections of S. maltophilia… 

Update on infections caused by Stenotrophomonas maltophilia with particular attention to resistance mechanisms and therapeutic options

A synthesis of information on current global trends in S. maltophilia pathogenicity as well as updated information on the molecular mechanisms contributing to its resistance to an array of antimicrobial agents is provided.

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The present review summarizes the literature data regarding extracellular and cell-associated virulence factors of S. maltophilia and considers the basic characteristics of biofilm formation.

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Cooperativity between Stenotrophomonas maltophilia and Pseudomonas aeruginosa during Polymicrobial Airway Infections

The results of this study indicate that S. maltophilia transiently colonizes the lung accompanied by significant weight loss and immune cell infiltration and the expression of early inflammatory markers, including interleukin 6 (IL-6), IL-1α, and tumor necrosis factor alpha (TNF-α) and these organisms colocalize in the lung during dual-species infection.

A Stenotrophomonas maltophilia Strain Evades a Major Caenorhabditis elegans Defense Pathway

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New strategies against Stenotrophomonas maltophilia: a serious worldwide intrinsically drug-resistant opportunistic pathogen

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  • Biology, Medicine
    Expert review of anti-infective therapy
  • 2014
This editorial reports on newer drugs and antimicrobial strategies and their potential for use in treatment of S. maltophilia infections, the development of new technologies to detect this organism, and identifies strategies currently in use to reduce transmission of this pathogen.

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Stenotrophomonas maltophilia relates to an aerobic, gram-negative, motile, as well as non-fermentative bacillus widely considered an opportunistic pathogen. In most cases, it leads to infection in

Antimicrobial Susceptibility of Stenotrophomonas maltophilia Clinical Isolates from Blood Samples in Iran

increasing rate of immunocompromised patients, prolonged consumption of antibiotics in hospitalized patients and some genetic disorders like cystic fibrosis make it essential to monitor S. maltophilia drug resistance status.



Microbiological and Clinical Aspects of Infection Associated with Stenotrophomonas maltophilia

The current taxonomic status of S. maltophilia is reviewed, the epidemiology of the organism is considered with particular reference to nosocomial outbreaks, and the laboratory identification of the bacterium is discussed.

Immunostimulatory Properties of the Emerging Pathogen Stenotrophomonas maltophilia

The immunostimulatory properties of this organism and its induction of TNF-α expression specifically indicate that it is likely to contribute significantly to airway inflammation.

Antimicrobial therapy for Stenotrophomonas maltophilia infections

  • A. NicodemoJ. Paez
  • Biology, Medicine
    European Journal of Clinical Microbiology & Infectious Diseases
  • 2007
The main resistance mechanisms, the in vitro susceptibility profile, and treatment options for S. maltophilia infections are described and trimethoprim-sulfamethoxazole remains the drug of choice, although in vitro studies indicate that ticarcillin-clavulanic acid, minocycline, some of the new fluoroquinolones, and tigecycline may be useful agents.

Stenotrophomonas maltophilia: changing spectrum of a serious bacterial pathogen in patients with cancer.

  • A. SafdarK. Rolston
  • Biology, Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2007
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Community-acquired Stenotrophomonas maltophilia infections: a systematic review

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Stenotrophomonas maltophilia in Salad

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Stenotrophomonas maltophilia drug resistance.

Future studies are required to fully understand the mechanisms of resistance, their regulation and potential crosstalk with S. maltophilia virulence, as well as the population dynamics of the different isolates of this bacterial species.

Identification and Detection ofStenotrophomonas maltophilia by rRNA-Directed PCR

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Molecular Characterization of Virulence Determinants of Stenotrophomonas Maltophilia Strains Isolated from Patients Affected by Cystic Fibrosis

The authors' data indicate that the different degree of biofilm formation exhibited by the 11 CF isolates does not correlate with motility, ability to adhere to and invade A549 cells, or with the presence of flagella.

Characterization of Flagella Produced by Clinical Strains of Stenotrophomonas maltophilia

Ulastructural analysis by scanning electron microscopy of bacteria adhering to plastic showed flagellalike structures within the bacterial clusters, suggesting that flagella are produced as the bacteria spread on the abiotic surface.