Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

@article{Brooke2012StenotrophomonasMA,
  title={Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen},
  author={Joanna S. Brooke},
  journal={Clinical Microbiology Reviews},
  year={2012},
  volume={25},
  pages={2 - 41}
}
  • J. Brooke
  • Published 1 January 2012
  • Biology, Medicine
  • Clinical Microbiology Reviews
SUMMARY Stenotrophomonas maltophilia is an emerging multidrug-resistant global opportunistic pathogen. The increasing incidence of nosocomial and community-acquired S. maltophilia infections is of particular concern for immunocompromised individuals, as this bacterial pathogen is associated with a significant fatality/case ratio. S. maltophilia is an environmental bacterium found in aqueous habitats, including plant rhizospheres, animals, foods, and water sources. Infections of S. maltophilia… 

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  • J. Brooke
  • Biology, Medicine
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  • 2014
This editorial reports on newer drugs and antimicrobial strategies and their potential for use in treatment of S. maltophilia infections, the development of new technologies to detect this organism, and identifies strategies currently in use to reduce transmission of this pathogen.

An In-Depth Analysis of Stenotrophomonas maltophilia: A Multi-Drug ResistantPathogen

Stenotrophomonas maltophilia relates to an aerobic, gram-negative, motile, as well as non-fermentative bacillus widely considered an opportunistic pathogen. In most cases, it leads to infection in
...

References

SHOWING 1-10 OF 422 REFERENCES

Microbiological and Clinical Aspects of Infection Associated with Stenotrophomonas maltophilia

The current taxonomic status of S. maltophilia is reviewed, the epidemiology of the organism is considered with particular reference to nosocomial outbreaks, and the laboratory identification of the bacterium is discussed.

Immunostimulatory Properties of the Emerging Pathogen Stenotrophomonas maltophilia

The immunostimulatory properties of this organism and its induction of TNF-α expression specifically indicate that it is likely to contribute significantly to airway inflammation.

Antimicrobial therapy for Stenotrophomonas maltophilia infections

  • A. NicodemoJ. Paez
  • Biology, Medicine
    European Journal of Clinical Microbiology & Infectious Diseases
  • 2007
The main resistance mechanisms, the in vitro susceptibility profile, and treatment options for S. maltophilia infections are described and trimethoprim-sulfamethoxazole remains the drug of choice, although in vitro studies indicate that ticarcillin-clavulanic acid, minocycline, some of the new fluoroquinolones, and tigecycline may be useful agents.

Stenotrophomonas maltophilia: changing spectrum of a serious bacterial pathogen in patients with cancer.

  • A. SafdarK. Rolston
  • Biology, Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2007
Agents that improve outer-membrane permeability and broad-spectrum beta-lactamase inhibitors may favorably impact difficult-to-treat S. maltophilia infections.

Stenotrophomonas (Xanthomonas) maltophilia as an Emerging Opportunistic Pathogen in Association with HIV Infection: A 10-Year Surveillance Study

Abstract.Background:Stenotrophomonas (Xanthomonas) maltophilia has been increasingly reported as a nosocomial opportunistic pathogen, responsible for serious infectious complications in

Community-acquired Stenotrophomonas maltophilia infections: a systematic review

The objective of this paper was to collect and evaluate the available published data referring to community-acquired S. maltophilia infections, and to be aware that S. Maltophilia infected patients are not restricted to hospitalized patients.

Stenotrophomonas maltophilia in Salad

The prevalence of S. maltophilia in salad vegetables and its growth characteristics in products of this type, especially if subject to temperature abuse, are unknown, but in the domestic setting, numbers of the bacterium may increase before use.

Stenotrophomonas maltophilia drug resistance.

Future studies are required to fully understand the mechanisms of resistance, their regulation and potential crosstalk with S. maltophilia virulence, as well as the population dynamics of the different isolates of this bacterial species.

Identification and Detection ofStenotrophomonas maltophilia by rRNA-Directed PCR

An SS-PCR protocol is developed that can rapidly and accurately identify S. maltophilia isolates and which can be used for the direct detection of this organism in CF patient sputum, and three samples were PCR positive, in complete concordance with the conventional laboratory culture.

Molecular Characterization of Virulence Determinants of Stenotrophomonas Maltophilia Strains Isolated from Patients Affected by Cystic Fibrosis

The authors' data indicate that the different degree of biofilm formation exhibited by the 11 CF isolates does not correlate with motility, ability to adhere to and invade A549 cells, or with the presence of flagella.
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