Stemona tuberosa prevented inflammation by suppressing the recruitment and the activation of macrophages in vivo and in vitro.

@article{Lim2015StemonaTP,
  title={Stemona tuberosa prevented inflammation by suppressing the recruitment and the activation of macrophages in vivo and in vitro.},
  author={Dahae Lim and Euijeong Lee and Eunyoung Jeong and Y. Jang and Jinju Kim},
  journal={Journal of ethnopharmacology},
  year={2015},
  volume={160},
  pages={
          41-51
        }
}
ETHNOPHARMACOLOGICAL RELEVANCE Stemona tuberosa (ST) is a traditional herbal medicine used for the treatment of various respiratory diseases in eastern Asia. AIM OF THE STUDY We investigated the anti-inflammatory effects of a ST water extract in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and in cigarette smoke (CS)-induced lung inflammation mouse models. MATERIALS AND METHODS RAW 264.7 macrophages were treated with the ST extract and stimulated by LPS. The expressions of pro… Expand
The therapeutic effect of Bletilla striata extracts on LPS-induced acute lung injury by regulation of inflammation and oxidation
Bletilla striata, a widely used traditional herbal medicine, has been shown to exhibit various biological activities but its antioxidative and anti-inflammatory activities have not been well studied.Expand
Tuberostemonine N, an active compound isolated from Stemona tuberosa, suppresses cigarette smoke-induced sub-acute lung inflammation in mice.
TLDR
Data suggest that tuberostemonine N exerts anti-inflammatory effects against airway inflammation, and T.N may be a novel therapeutic agent for lung diseases, such as COPD. Expand
The therapeutic effects of tuberostemonine against cigarette smoke-induced acute lung inflammation in mice.
TLDR
The results suggest that TS has anti-inflammatory effects against CS-induced acute lung inflammation and significantly ameliorated the airway epithelial thickness induced by CS exposure and caused a significant decrement in the production of chemokines in the lung. Expand
Neotuberostemonine attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages.
TLDR
It is demonstrated for the first time that NTS has a significant protective effect on BLM-induced pulmonary fibrosis through suppressing the recruitment and M2 polarization of macrophages. Expand
The dichloromethane fraction from Mahonia bealei (Fort.) Carr. leaves exerts an anti-inflammatory effect both in vitro and in vivo.
TLDR
It is indicated that MBL-CH attenuates LPS-stimulated inflammatory responses in macrophages by blocking NF-κB activation through interference with activation of the PI3K/Akt pathway, providing scientific evidence that the plant can be employed in traditional remedies. Expand
Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung
TLDR
It is indicated that macrophage depletion by clodronate liposome treatment attenuates CS-induced inflammatory response in both the lung and colon. Expand
Original Research: Extract of Bambusae Caulis in Taeniam inhibits cigarette smoke-induced pulmonary and intestinal inflammation
TLDR
Results showed that Bambusae Caulis in Taeniam attenuated cigarette smoke-induced inflammatory response in both the lung and the bowel of mice by inhibiting the production of pro-inflammatory cytokines, chemokines, and protease as well as NF-κB signaling factor. Expand
Neotuberostemonine inhibits osteoclastogenesis via blockade of NF-κB pathway.
TLDR
It is found that Neotuberostemonine inhibits RANKL- or cancer cell-mediated osteoclastogenesis via blockade of TRAF6 and NF-κB activation and impairs the formation of F-actin ring structure, an important feature of osteOClast differentiation and function. Expand
The traditional uses, phytochemistry, and pharmacology of Stemona species: A review.
TLDR
Though plants of genus Stemona have been put to enormous traditional uses, the pharmacological studies conducted were insufficient and further studies are also required to establish the mechanisms which mediate the plants' bioactivities in relation to the medicinal uses and investigate any potential toxicity for future clinical studies. Expand
A Pharmacological Strategy Using Stemofoline for more Efficacious Chemotherapeutic Treatments Against Human Multidrug Resistant Leukemic Cells
TLDR
The results suggest that the accumulation of DOX enhanced by STF was sufficient to induce cell cycle arrest in K562/Adr, which supports the previous in vitro data and indicates the possibility of developing STF as an adjuvant therapy in cancer treatments. Expand
...
1
2
...

References

SHOWING 1-10 OF 43 REFERENCES
Effects of Schisandra chinensis Baillon (Schizandraceae) on lipopolysaccharide induced lung inflammation in mice.
TLDR
Findings indicate that Schisandra chinensis Baillon extracts could be potentially useful for the treatment of acute lung inflammation and acute lung injury. Expand
A herbal formula containing roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibits inflammatory mediators in LPS-stimulated RAW 264.7 macrophages through inhibition of nuclear factor κB (NFκB) pathway.
TLDR
The present study demonstrated that DG could suppress the production of NO and PGE(2) through the inhibition of iNOS and COX-2 genes and elucidate its underlying mechanisms with regards to its molecular basis of action. Expand
Bambusae Caulis in Taeniam extract reduces ovalbumin-induced airway inflammation and T helper 2 responses in mice.
TLDR
Investigation of the suitability of BC extract as a therapeutic candidate in the treatment of allergic airway disease in ovalbumin-induced asthma model indicated thatBC extract reduces OVA-induced airway inflammation and Th 2 response in mice, suggesting that BC extract can be a therapeutic candidates for allergic airways disease, including asthma. Expand
Galla Chinensis Attenuates Cigarette Smoke‐associated Lung Injury by Inhibiting Recruitment of Inflammatory Cells into the Lung
TLDR
Results show that GC extract reduces lung inflammation and emphysematous change by inhibiting the infiltration of inflammatory cells to the lung by reducing MCP‐1 production in a dose‐dependent manner. Expand
Lilium lancifolium Thunb. extract attenuates pulmonary inflammation and air space enlargement in a cigarette smoke-exposed mouse model.
ETHNOPHARMACOLOGICAL RELEVANCE Lilium lancifolium Thunb. (Liliaceae) has long been used as a traditional medicine in Korea and China to treat bronchitis, pneumonia, and other pulmonary ailments. Expand
Proteolytically Inactive Per a 10 Allergen of Periplaneta americana Modulates Th2 Response and Enhances IL-10 in Mouse Model
TLDR
Investigating the efficacy of purified cockroach allergen immunotherapy with proteolytically active and inactive Per a 10 in allergic mouse model shows significant reduction in IgE levels in serum, IL-4 levels in BAL fluid, CS, and eosinophilic infiltration in lungs than PBS-treated mice. Expand
Substance P enhances NF-kappaB transactivation and chemokine response in murine macrophages via ERK1/2 and p38 MAPK signaling pathways.
TLDR
The data demonstrate that SP enhances selective inflammatory chemokine production by murine macrophages via ERK/p38 MAPK-mediated NF-kappaB activation, suggesting that the two MAPKs lie in the signaling pathways leading to theChemokine response. Expand
Macrophage elastase (MMP-12): a pro-inflammatory mediator?
TLDR
The instillation of a recombinant form of human MMP-12 in mouse airways induced a severe inflammatory cell recruitment characterized by an early accumulation of neutrophils correlated with an increase in proinflammatory cytokines and in gelatinases and indicated that the model could mimic some of the inflammatory features observed in COPD patients and could be used for the pharmacological evaluation of new anti-inflammatory treatment. Expand
Antitussive activity of Stemona alkaloids from Stemona tuberosa.
TLDR
It is demonstrated, for the first time, that compounds 1 and 5 showed significant antitussive activities in guinea pig after cough induction by citric acid aerosol stimulation. Expand
Antitussive and central respiratory depressant effects of Stemona tuberosa.
TLDR
Croomine acts on central sites in the cough reflex pathway and demonstrates central respiratory depressant effects, which can partly account for the adverse reactions reported for the herb. Expand
...
1
2
3
4
5
...