Stem cells reprogrammed using chemicals alone

  title={Stem cells reprogrammed using chemicals alone},
  author={D. Cyranoski},
Patient-specific cells could be made without genetic manipulation. 
Stem cell therapy: a look at current research, regulations, and remaining hurdles.
  • M. Reisman, K. Adams
  • Medicine, Biology
  • P & T : a peer-reviewed journal for formulary management
  • 2014
This research highlights the need to understand more fully the “why” and “how” of cell reprograming, as well as the types of cells that can be reprogramed for use in various medical conditions. Expand
Stem Cells and Organ Transplantation: Resetting Our Biological Clocks
The human body has only a limited ability to repair itself and can at best only partly regenerate the authors' organs and cannot grow back a whole limb. Expand
Promotion of Cell-Based Therapy: Special Focus on the Cooperation of Mesenchymal Stem Cell Therapy and Gene Therapy for Clinical Trial Studies.
This study has been focused on genetically modified MSCs for use in RM with an emphasis on CTSs and highlights the basic concept of genetic modifications and also discusses recent clinical studies aspects. Expand
Chromatographie cellulaire d'affinité : étude expérimentale des mécanismes de capture spécifique et implications pour un développement industriel
Cette these a pour objectif le developpement d'une technologie de tri cellulaire reposant sur le principe de la chromatographie d'affinite, pour des applications medicales. Pour cela les mecanismesExpand


Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds
It is shown that pluripotent stem cells can be generated from mouse somatic cells at a frequency up to 0.2% using a combination of seven small-molecule compounds, which resemble embryonic stem cells in terms of their gene expression profiles, epigenetic status, and potential for differentiation and germline transmission. Expand
Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules
This work identifies a specific chemical combination, which is sufficient to permit reprogramming from mouse embryonic and adult fibroblasts in the presence of a single transcription factor, Oct4, within 20 days, replacing Sox2, Klf4 and c-Myc. Expand
Reprogramming of human primary somatic cells by OCT4 and chemical compounds.
A small molecule cocktail is reported that enables reprogramming of human primary somatic cells to iPSCs with exogenous expression of only OCT4, and mechanistic studies revealed that modulation of cell metabolism from mitochondrial oxidation to glycolysis plays an important role in reprograming. Expand
Dedifferentiation and the role of sall4 in reprogramming and patterning during amphibian limb regeneration
  • A. Neff, M. King, A. Mescher
  • Biology, Medicine
  • Developmental dynamics : an official publication of the American Association of Anatomists
  • 2011
Sall4 is involved in maintenance of ESC pluripotency, is a major repressor of differentiation, plays a major role in reprogramming differentiated cells into iPSCs, and is a component of the stemness regulatory circuit of pluripotent ESCs andiPSCs. Expand