Stem cells marked by the R-spondin receptor LGR5.

Abstract

Since the discovery of LGR5 as a marker of intestinal stem cells, the field has developed explosively and led to many new avenues of research. The inner workings of the intestinal crypt stem cell niche are now well understood. The study of stem cell-enriched genes has uncovered some previously unknown aspects of the Wnt signaling pathway, the major driver… (More)
DOI: 10.1053/j.gastro.2014.05.007

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