Stem cells increase in numbers in perinecrotic areas in human renal cancer.

Abstract

PURPOSE Developing strategies to overcome resistance to sunitinib is a major challenge in human renal cell carcinoma (RCC). We hypothesized that sunitinib-induced tumor necrosis-associated hypoxia could interact with renal cancer stem cells in patients with metastatic RCC. EXPERIMENTAL DESIGN We studied tissue samples from 7 patients with primary… (More)
DOI: 10.1158/1078-0432.CCR-14-0666

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@article{Varna2015StemCI, title={Stem cells increase in numbers in perinecrotic areas in human renal cancer.}, author={Mariana Varna and Guillaume Gapihan and Jean-Paul Feugeas and Philippe Ratajczak and Sophie Tan and Irmine Ferreira and Christophe Leboeuf and Niclas Setterblad and Arnaud Duval and J{\'e}r{\^o}me V{\'e}rine and St{\'e}phane Germain and Pierre Mongiat-Artus and Anne Janin and Guilhem Bousquet}, journal={Clinical cancer research : an official journal of the American Association for Cancer Research}, year={2015}, volume={21 4}, pages={916-24} }