Stem cells in the spleen: therapeutic potential for Sjogren's syndrome, type I diabetes, and other disorders.

@article{Faustman2010StemCI,
  title={Stem cells in the spleen: therapeutic potential for Sjogren's syndrome, type I diabetes, and other disorders.},
  author={Denise L Faustman and Miriam A Davis},
  journal={The international journal of biochemistry & cell biology},
  year={2010},
  volume={42 10},
  pages={1576-9}
}
The view of the spleen as an unnecessary organ has been shattered. The evidence shows the spleen to be a source of naturally-occurring multipotent stem cells with possibly pluripotent potential. The stem cells are sequestered in the spleen of not only of animals but also of normal human adults. The reservoir of cells is set for differentiation and they need not be manipulated in vitro or ex vivo before autologous or heterologous use. Splenic stem cells, of Hox11 lineage, have been found in… CONTINUE READING

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