Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis

@article{Ito2005StemCI,
  title={Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis},
  author={Mayumi Ito and Yaping Liu and Zaixin Yang and Jane Q. Nguyen and Fan Liang and Rebecca J. Morris and George Cotsarelis},
  journal={Nature Medicine},
  year={2005},
  volume={11},
  pages={1351-1354}
}
The discovery of long-lived epithelial stem cells in the bulge region of the hair follicle led to the hypothesis that epidermal renewal and epidermal repair after wounding both depend on these cells. To determine whether bulge cells are necessary for epidermal renewal, here we have ablated these cells by targeting them with a suicide gene encoding herpes simplex virus thymidine kinase (HSV-TK) using a Keratin 1–15 (Krt1-15) promoter. We show that ablation leads to complete loss of hair… 
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