Stem cells in squamous head and neck cancer.

  title={Stem cells in squamous head and neck cancer.},
  author={Andreas E Albers and Chao Chen and Beate K{\"o}berle and Xu Qian and Jens Klu\ssmann and Barbara Wollenberg and Andreas M Kaufmann},
  journal={Critical reviews in oncology/hematology},
  volume={81 3},
The initiation and metastasis of head and neck squamous cell carcinomas (HNSCC) and other cancers have recently been related to the presence of cancer stem cells (CSC). CSC are cancer initiating, sustaining and are mostly quiescent. Specific markers that vary considerably depending on tumor type or tissue of origin characterize putative CSC. Compared to the bulk tumor mass, CSC are less sensitive to chemo- and radiotherapy and may also have low immunogenicity. Therapeutic targeting of CSC may… CONTINUE READING
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