Stem cells in genetically-engineered mouse models of prostate cancer.

Abstract

The cancer stem cell model proposes that tumors have a hierarchical organization in which tumorigenic cells give rise to non-tumorigenic cells, with only a subset of stem-like cells able to propagate the tumor. In the case of prostate cancer, recent analyses of genetically engineered mouse (GEM) models have provided evidence supporting the existence of… (More)
DOI: 10.1530/ERC-15-0367

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