Stem cells genetically modified with the developmental gene MT1-MMP improve regeneration of the supraspinatus tendon-to-bone insertion site.

@article{Gulotta2010StemCG,
  title={Stem cells genetically modified with the developmental gene MT1-MMP improve regeneration of the supraspinatus tendon-to-bone insertion site.},
  author={Lawrence Vincent Gulotta and David Kova{\vc}evi{\'c} and Scott K. Montgomery and John R. Ehteshami and Jonathon D Packer and Scott A Rodeo},
  journal={The American journal of sports medicine},
  year={2010},
  volume={38 7},
  pages={
          1429-37
        }
}
BACKGROUND Rotator cuffs heal through a scar tissue interface after repair, which makes them prone to failure. Membrane type 1 matrix metalloproteinase (MT1-MMP) is upregulated during embryogenesis in areas that develop into tendon-bone insertion sites. HYPOTHESIS Bone marrow-derived stem cells in the presence of the developmental signal from MT1-MMP will drive the healing process toward regeneration and away from scar formation. STUDY DESIGN Controlled laboratory study. METHODS Sixty… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 79 CITATIONS, ESTIMATED 49% COVERAGE

Assembly, maturation, and degradation of the supraspinatus enthesis.

  • Journal of shoulder and elbow surgery
  • 2018
VIEW 5 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

University of Southern Denmark Assembly , maturation and degradation of the supraspinatus

enthesis, jensen, Kate Lykke, Lars Henrik
  • 2018
VIEW 5 EXCERPTS
HIGHLY INFLUENCED

The future role of mesenchymal stem cells in the management of shoulder disorders.

  • Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • 2013
VIEW 5 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

Stem Cells for Augmenting Tendon Repair

VIEW 3 EXCERPTS
CITES BACKGROUND

FILTER CITATIONS BY YEAR

2010
2019

CITATION STATISTICS

  • 6 Highly Influenced Citations

  • Averaged 6 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Tendon and ligament insertion. A light and electron microscopic study.

  • The Journal of bone and joint surgery. American volume
  • 1970
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL