Stem cells for murine interstitial cells of cajal suppress cellular immunity and colitis via prostaglandin E2 secretion.

@article{Dave2015StemCF,
  title={Stem cells for murine interstitial cells of cajal suppress cellular immunity and colitis via prostaglandin E2 secretion.},
  author={Maneesh Dave and Yujiro Hayashi and Gabriella Bedekovicsne Gajdos and Thomas C. Smyrk and Phyllis A. Svingen and Sergiy M. Kvasha and Andrea Lorincz and Haidong Dong and William A. Faubion and Tamas Ordog},
  journal={Gastroenterology},
  year={2015},
  volume={148 5},
  pages={978-90}
}
BACKGROUND & AIMS After allogeneic transplantation, murine stem cells (SCs) for interstitial cells of Cajal (ICCs), electrical pacemaker, and neuromodulator cells of the gut, were incorporated into gastric ICC networks, indicating in vivo immunosuppression. Immunosuppression is characteristic of bone marrow- and other non-gut-derived mesenchymal stem cells (MSCs), which are emerging as potential therapeutic agents against autoimmune diseases, including inflammatory bowel disease. Therefore, we… CONTINUE READING

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Indomethacin , a cyclooxygenase inhibitor , countered the ICC - SC - mediated suppression of T - cell proliferation .
Indomethacin , a cyclooxygenase inhibitor , countered the ICC - SC - mediated suppression of T - cell proliferation .
Indomethacin , a cyclooxygenase inhibitor , countered the ICC - SC - mediated suppression of T - cell proliferation .
Indomethacin , a cyclooxygenase inhibitor , countered the ICC - SC - mediated suppression of T - cell proliferation .
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