Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency.

@article{Tailor2013StemCE,
  title={Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency.},
  author={Jignesh Tailor and Raja Kittappa and Ketty Leto and Monte A. Gates and Melodie Borel and Ole Paulsen and Sonia O. Spitzer and Ragnhildur Th{\'o}ra K{\'a}rad{\'o}ttir and Ferdinando Dott. Rossi and Anna Helena Falk and Austin G. Smith},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 30},
  pages={12407-22}
}
Stem cell lines that faithfully maintain the regional identity and developmental potency of progenitors in the human brain would create new opportunities in developmental neurobiology and provide a resource for generating specialized human neurons. However, to date, neural progenitor cultures derived from the human brain have either been short-lived or exhibit restricted, predominantly glial, differentiation capacity. Pluripotent stem cells are an alternative source, but to ascertain… CONTINUE READING
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