Stem cells and their niches.


A constellation of intrinsic and extrinsic cellular mechanisms regulates the balance of self-renewal and differentiation in all stem cells. Stem cells, their progeny, and elements of their microenvironment make up an anatomical structure that coordinates normal homeostatic production of functional mature cells. Here we discuss the stem cell niche concept… (More)


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@article{Moore2006StemCA, title={Stem cells and their niches.}, author={Kateri Moore and Ihor Lemischka}, journal={Science}, year={2006}, volume={311 5769}, pages={1880-5} }