Stem cells and rat liver carcinogenesis: contributions of confocal and electron microscopy.

@article{Novikoff1998StemCA,
  title={Stem cells and rat liver carcinogenesis: contributions of confocal and electron microscopy.},
  author={Phyllis M. Novikoff and A Yam},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={1998},
  volume={46 5},
  pages={613-26}
}
Microscopic analysis in combination with cytochemistry and immunocytochemistry has revealed the presence of four cell types not previously described in the portal area and parenchyma of the liver from an experimental rodent hepatocarcinogenic rat model. Within the intrahepatic bile ductules, which proliferate after administration of chemical carcinogens and partial hepatectomy, small, undifferentiated nonpolarized, nonepithelial cells with a blast-like phenotype and polarized epithelial cells… CONTINUE READING