Stem cells and gastric cancer: role of gastric and intestinal mixed intestinal metaplasia.

@article{Tatematsu2003StemCA,
  title={Stem cells and gastric cancer: role of gastric and intestinal mixed intestinal metaplasia.},
  author={Masae Tatematsu and Tetsuya Tsukamoto and Kenichi Inada},
  journal={Cancer science},
  year={2003},
  volume={94 2},
  pages={135-41}
}
All of the different types of stomach epithelial cells are known to be derived from a single progenitor cell in each gland. Similarly, cancers develop from single cells, based on data from clonality analysis in C3H/HeN<-->BALB/c chimeric mice. Using gastric and intestinal epithelial cell markers, intestinal metaplasia (IM) can be divided into two major types: a gastric and intestinal (GI) mixed type, and a solely intestinal (I) type. Ectopic expression of Cdx genes and down-regulation of Sox2… CONTINUE READING
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