Stem cells and clinical practice: new advances and challenges at the time of emerging problems with induced pluripotent stem cell therapies.

@article{Ratajczak2016StemCA,
  title={Stem cells and clinical practice: new advances and challenges at the time of emerging problems with induced pluripotent stem cell therapies.},
  author={Mariusz Z. Ratajczak and Kamila Bujko and Wojciech Wojakowski},
  journal={Polskie Archiwum Medycyny Wewnetrznej},
  year={2016},
  volume={126 11},
  pages={
          879-890
        }
}
Humans, like other species that reproduce sexually, originate from a fertilized oocyte (zygote), which is a totipotent stem cell giving rise to an adult organism. During the process of embryogenesis, stem cells at different levels of the developmental hierarchy establish all 3 germ layers and give rise to tissue‑committed stem cells, which are responsible for rejuvenation of a given tissue or organ. The robustness of the stem cell compartment is one of the major factors that directly impact… 

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