Stem cells: comprehensive treatments for amyotrophic lateral sclerosis in conjunction with growth factor delivery.

@article{Lunn2009StemCC,
  title={Stem cells: comprehensive treatments for amyotrophic lateral sclerosis in conjunction with growth factor delivery.},
  author={J. Simon Lunn and Michael P. Hefferan and Martin Marsala and Eva L. Feldman},
  journal={Growth factors},
  year={2009},
  volume={27 3},
  pages={133-40}
}
Amyotrophic lateral sclerosis (ALS) is characterized by loss of both upper and lower motor neurons. ALS progression is complex and likely due to cellular dysfunction at multiple levels, including mitochondrial dysfunction, glutamate excitotoxicity, oxidative stress, axonal dysfunction, reactive astrocytosis, and mutant superoxide dismutase expression, therefore, treatment must provide neuronal protection from multiple insults. A significant amount of ALS research focuses on growth factor-based… CONTINUE READING
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