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Hox gene expression determines cell fate of adult periosteal stem/progenitor cells
- Medicine, BiologyScientific Reports
It is shown that Hox genes are expressed in periosteal stem/progenitor cells in a distribution similar to that during embryonic development, and the modulatory role of Hox proteins in fate decisions may offer potential druggable targets for the treatment of fractures, non-unions and bone defects.
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Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential
- Medicine, BiologyCell
Grem1 expression identifies distinct connective tissue stem cells in both the bone (OCR stem cells) and the intestine (iRSCs) that are cells of origin for the periepithelial intestinal mesenchymal sheath.
Identification and Specification of the Mouse Skeletal Stem Cell
- Biology, MedicineCell
It is demonstrated that m SSC niche factors can be potent inducers of osteogenesis, and several specific combinations of recombinant mSSC niche Factors can activate mSSCs genetic programs in situ, even in nonskeletal tissues, resulting in de novo formation of cartilage or bone and bone marrow stroma.