Stem cell transplantation in Multiple Sclerosis: Safety and Ethics

@article{Silani2008StemCT,
  title={Stem cell transplantation in Multiple Sclerosis: Safety and Ethics},
  author={V. Silani and L. Cova},
  journal={Journal of the Neurological Sciences},
  year={2008},
  volume={265},
  pages={116-121}
}
Stem cell therapy is considered a promising strategy aiming at neuronal and glial cell replacement or neuroprotection in neurological diseases affecting the brain and spinal cord. Multiple Sclerosis (MS), characterized by inflammation-induced destruction of the myelin sheath surrounding axons leading to conduction deficits and variability of clinical signs, is not an exception. MS is considered an autoimmune disease and, in the last few years, an intense immunodepletion followed by autologous… Expand
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References

SHOWING 1-10 OF 38 REFERENCES
Autologous stem cell transplantation as rescue therapy in malignant forms of multiple sclerosis
TLDR
The treatment with intense immune ablation followed by ASCT of three patients with malignant MS whose clinical course indicated a dramatically poor prognosis succeeded in halting the rapidly worsening course of disease. Expand
Stem-cell therapy for amyotrophic lateral sclerosis
CONTEXT With the lack of effective drug treatments for amyotrophic lateral sclerosis (ALS), and compelling preclinical data, stem-cell research has highlighted this disease as a candidate forExpand
Autologous Stem Cell Transplantation in Progressive Multiple Sclerosis—An Interim Analysis of Efficacy
TLDR
These results appear better than those achieved by any other treatment of progressive multiple sclerosis, including beta-interferon, but they need to be confirmed by other open or controlled studies in view of the well-known difficulty of judging objectively the effect of a treatment in patients with this disease. Expand
Autologous haematopoietic stem cell transplantation fails to stop demyelination and neurodegeneration in multiple sclerosis.
TLDR
The present results indicate that ongoing demyelination and axonal degeneration exist despite pronounced immunosuppression in multiple sclerosis patients with high expanded disability system scores despite autologous stem cell transplantation. Expand
Autologous haematopoietic-stem-cell transplantation for multiple sclerosis
TLDR
The course of MS seems to be stabilised after autologous HSCT, especially in ambulatory patients with evidence of active disease, and the treatment deserves further study in randomised controlled trials. Expand
Stem therapy for ALS: hope and reality.
  • V. Silani, N. Leigh
  • Medicine
  • Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
  • 2003
TLDR
The recent breakthroughs in stem cell research might nevertheless provide possibilities for neural implantation and cell replacement therapy for patients with ALS, as well as the potential impact of these new approaches to neurodegenerative diseases. Expand
Intense immunosuppression followed by autologous stem cell transplantation in severe multiple sclerosis
TLDR
The results of the Italian phase 2 GITMO study support a role for intense immunosuppression followed by ASCT as treatment in rapidly evolving MS cases unresponsive to conventional therapies. Expand
Stem Cell Therapy for ALS: Hope and RealityA discussion paper from the Executive of the European ALS Consortium
TLDR
The recent breakthroughs in stem cell research might nevertheless provide possibilities for neural implantation and cell replacement therapy for patients with ALS, as well as the potential impact of these new approaches to neurodegenerative diseases. Expand
Autologous Peripheral Blood Stem Cell Transplantation for Severe Multiple Sclerosis
  • L. Su, J. Xu, +5 authors D. Lu
  • Medicine
  • International journal of hematology
  • 2006
TLDR
Autologous hematopoietic stem cell transplantation (auto-HSCT) proved to be safe and beneficial for some MS patients and further studies are needed to establish the merit of this procedure for MS patients. Expand
Hematopoietic stem cell transplantation for multiple sclerosis
TLDR
Autologous HSCT suggest positive early results in the management of progressive MS and is feasible and is being utilised in the planning of future trials to reduce transplant related mortality. Expand
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