Stem cell transplantation: the lung barrier.

  title={Stem cell transplantation: the lung barrier.},
  author={Sonja Schrepfer and Tobias Deuse and Hermann C Reichenspurner and Michael P. Fischbein and Robert Clayton Robbins and Marc P Pelletier},
  journal={Transplantation proceedings},
  volume={39 2},
BACKGROUND Mesenchymal stem cells (MSCs) show differentiation capacity along mesenchymal lineages and have the potential to aid tissue regeneration. MSC transplantation strategies are therefore currently being assessed following injury to various organs. However, potential MSC migration to these organs after intravenous (IV) MSC injection continues to be impeded by cell trapping within the lung. METHODS Mouse MSCs were isolated, purified, transfected with firefly luciferase, and labeled with… CONTINUE READING


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