Stem cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-cadherin and FoxJ1 and contributes to adverse clinical outcome in ovarian cancers

@article{Siu2013StemCT,
  title={Stem cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-cadherin and FoxJ1 and contributes to adverse clinical outcome in ovarian cancers},
  author={M K-Y Siu and Emily S Wong and Daniel S. H. Kong and Helen Yau-Tsz Chan and Li Jiang and O G Wong and Eric W-F Lam and Karen Kar-Loen Chan and Hextan Y. S. Ngan and X Le and Annie N. Y. Cheung},
  journal={Oncogene},
  year={2013},
  volume={32},
  pages={3500-3509}
}
Ovarian cancer is the most lethal of all gynecological malignancies, and the identification of novel prognostic and therapeutic targets for ovarian cancer is crucial. It is believed that only a small subset of cancer cells are endowed with stem cell properties, which are responsible for tumor growth, metastatic progression and recurrence. NANOG is one of the key transcription factors essential for maintaining self-renewal and pluripotency in stem cells. This study investigated the role of NANOG… CONTINUE READING

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