Stem cell recruitment after injury: lessons for regenerative medicine.

Abstract

Tissue repair and regeneration are thought to involve resident cell proliferation as well as the selective recruitment of circulating stem and progenitor cell populations through complex signaling cascades. Many of these recruited cells originate from the bone marrow, and specific subpopulations of bone marrow cells have been isolated and used to augment adult tissue regeneration in preclinical models. Clinical studies of cell-based therapies have reported mixed results, however, and a variety of approaches to enhance the regenerative capacity of stem cell therapies are being developed based on emerging insights into the mechanisms of progenitor cell biology and recruitment following injury. This article discusses the function and mechanisms of recruitment of important bone marrow-derived stem and progenitor cell populations following injury, as well as the emerging therapeutic applications targeting these cells.

DOI: 10.2217/rme.12.82

4 Figures and Tables

0204020132014201520162017
Citations per Year

69 Citations

Semantic Scholar estimates that this publication has 69 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Rennert2012StemCR, title={Stem cell recruitment after injury: lessons for regenerative medicine.}, author={Robert C . Rennert and Michael Sorkin and Ravi Kumar Garg and Geoffrey C. Gurtner}, journal={Regenerative medicine}, year={2012}, volume={7 6}, pages={833-50} }