Stem cell mobilization with plerixafor and healing of diabetic ischemic wounds: A phase IIa, randomized, double‐blind, placebo‐controlled trial

  title={Stem cell mobilization with plerixafor and healing of diabetic ischemic wounds: A phase IIa, randomized, double‐blind, placebo‐controlled trial},
  author={Benedetta Maria Bonora and Roberta Cappellari and Marta Mazzucato and Mauro Rigato and Marco Grasso and Mirko Menegolo and Andrea Bruttocao and Angelo Avogaro and Gian Paolo Fadini},
  journal={Stem Cells Translational Medicine},
  pages={965 - 973}
Abstract Bone marrow‐derived cells contribute to tissue repair, but traffic of hematopoietic stem/progenitor cells (HSPCs) is impaired in diabetes. We therefore tested whether HSPC mobilization with the CXCR4 antagonist plerixafor improved healing of ischemic diabetic wounds. This was a pilot, phase IIa, double‐blind, randomized, placebo‐controlled trial (NCT02790957). Patients with diabetes with ischemic wounds were randomized to receive a single subcutaneous injection of plerixafor or saline… 
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