Stem cell mobilization with cyclophosphamide overcomes the suppressive effect of lenalidomide therapy on stem cell collection in multiple myeloma.

@article{Mark2008StemCM,
  title={Stem cell mobilization with cyclophosphamide overcomes the suppressive effect of lenalidomide therapy on stem cell collection in multiple myeloma.},
  author={Tomer M. Mark and Jessica L Stern and Jessica R Furst and David S Jayabalan and Faiza Zafar and April Larow and Roger Niles Pearse and John G. Harpel and Tsiporah B. Shore and Michael W. Schuster and John P. Leonard and Paul J. Christos and Morton Coleman and Rub{\'e}n Niesvizky},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2008},
  volume={14 7},
  pages={795-8}
}
A total of 28 treatment-naïve patients with stage II or III multiple myeloma (MM) were treated with the combination of clarithromycin, lenalidomide, and dexamethasone (BiRD). Stem cells were collected following granulocyte-colony stimulating factor (G-CSF) or cyclophosphamide (Cy) plus G-CSF mobilization at maximum response. Sufficient stem cells for 2 autologous stem cell transplants were collected from all patients mobilized with Cy plus G-CSF, versus 33% mobilized with G-CSF alone (P < .0001… CONTINUE READING

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