Stem cell mobilization by hyperbaric oxygen.

@article{Thom2006StemCM,
  title={Stem cell mobilization by hyperbaric oxygen.},
  author={S. Thom and V. Bhopale and O. Velazquez and L. Goldstein and Lynne H. Thom and D. Buerk},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={290 4},
  pages={
          H1378-86
        }
}
  • S. Thom, V. Bhopale, +3 authors D. Buerk
  • Published 2006
  • Biology, Chemistry, Medicine
  • American journal of physiology. Heart and circulatory physiology
We hypothesized that exposure to hyperbaric oxygen (HBO(2)) would mobilize stem/progenitor cells from the bone marrow by a nitric oxide (*NO) -dependent mechanism. The population of CD34(+) cells in the peripheral circulation of humans doubled in response to a single exposure to 2.0 atmospheres absolute (ATA) O(2) for 2 h. Over a course of 20 treatments, circulating CD34(+) cells increased eightfold, although the overall circulating white cell count was not significantly increased. The number… Expand

Paper Mentions

Observational Clinical Trial
This is an observational research study whose purposes are to see the effects of repeated hyperbaric oxygen therapy treatments on the levels of stem/progenitor cells in peripheral… Expand
ConditionsChanges in Peripheral Blood Population Numbers and Type.
InterventionOther
CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen - changes with oxygen dosage.
TLDR
It is concluded that putative progenitor cell mobilization is higher with 2.5 versus 2.0 ATA treatments, and all newly mobilized cells exhibit higher concentrations of an array of regulatory proteins. Expand
Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo.
TLDR
It is hypothesized that oxidative stress from hyperbaric oxygen exerts a trophic effect on vasculogenic stem cells by causing an oxidative stress that activates a physiological redox-active autocrine loop in SPCs that stimulates vasculogenesis. Expand
Age-dependent response of murine female bone marrow cells to hyperbaric oxygen
TLDR
The impact of aging on the response of BM SCPs to HBO is demonstrated and the potentially different age-related benefit of HBO in wound healing and tissue remodeling is indicated. Expand
Only minor stem cell mobilization in head and neck irradiated patients treated with hyperbaric oxygen.
TLDR
A minor statistically significant mobilizing effect of HBO treatment on the bone marrow derived stem/progenitor cell content in peripheral blood after 15 treatments, but no effect after 30 treatments is found. Expand
Hyperbaric oxygen induces placental growth factor expression in bone marrow-derived mesenchymal stem cells.
TLDR
HBO induced the expression of PlGF in human bone marrow-derived MSCs at least through the oxidative stress-related pathways, which may play an important role in HBO-induced vasculogenesis. Expand
Effect of intermittent hyperoxia on stem cell mobilization and cytokine expression
TLDR
The hypothesis that NBO induces a biological response similar to HBO, affecting serum stem progenitor cell populations and tumor necrosis factor-α concentration is supported. Expand
Hyperbaric oxygenation enhances transplanted cell graft and functional recovery in the infarct heart.
TLDR
Evaluating the effect of hyperbaric oxygenation on the engraftment of rat bone marrow-derived mesenchymal stem cells transplanted in infarct rat hearts found it to be a potential and clinically-viable adjuvant treatment for myocardial stem-cell therapy. Expand
Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: Increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy
  • S. Thom, T. Milovanova, +9 authors D. Margolis
  • Medicine
  • Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
  • 2011
TLDR
HBO2T stimulates vasculogenic stem cell mobilization from bone marrow of diabetics and more cells are recruited to skin wounds and nitric oxide synthase activity is acutely increased in patients' platelets following HBO2T and remains elevated for at least 20 hours. Expand
Effect of Hyperbaric Oxygen on Hematopoietic Stem Cell Transplantation
  • Omar S. Aljitawi
  • Medicine
  • 2019
In this chapter the accumulated evidence that supports the role of hyperbaric oxygen therapy (HBOT) in improving the process of hematopoietic stem/ progenitor cell (HSPC) homing, engraftment, andExpand
Lactate Stimulates Vasculogenic Stem Cells via the Thioredoxin System and Engages an Autocrine Activation Loop Involving Hypoxia-Inducible Factor 1
TLDR
Oxidative stress from lactate metabolism by SPCs accelerated further SPC recruitment and differentiation through Trx1-mediated elevations in HIF-1 levels and the subsequent synthesis of Hif-1-dependent growth factors. Expand
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TLDR
It is suggested that daily HBO treatment enhances the growth of fibroblasts when administered to a critical degree, and HBO appears to directly effect fibroblast production of autocrine growth factors on initial exposure. Expand
Characterization and quantitation of primitive hematopoietic progenitor cells present in peripheral blood autografts.
TLDR
Results suggest that peripheral blood mononuclear cells (PBMC) collected by leukapheresis following HD-CTX plus C-HGF mobilization contain not only differentiated HPC but also more primitive HPC. Expand
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TLDR
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TLDR
Examination of the expression of several angiogenesis-related genes in human umbilical vein endothelial cells exposed to HBO indicated that HBO-induced Ang2 expression may be through transcriptional stimulation, and requires the nitric oxide signaling pathway, which may play an important role in HBO- inducement. Expand
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TLDR
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TLDR
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TLDR
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TLDR
In an in vivo human model, it is found that the neo-intima formed on the surface of left ventricular assist devices is colonized with AC133(+)VEGFR-2(+) cells, suggesting a phenotypically and functionally distinct population of circulating endothelial cells that may play a role in neo-angiogenesis. Expand
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TLDR
Findings indicate that circulating EPCs are mobilized endogenously in response to tissue ischemia or exogenously by cytokine therapy and thereby augment neovascularization of ischemic tissues. Expand
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