Stem cell mobilization by hyperbaric oxygen

  title={Stem cell mobilization by hyperbaric oxygen},
  author={Stephen Thom and Veena M. Bhopale and Omaida C Velazquez and Lee Joshua Goldstein and Lynne H. Thom and Donald G. Buerk},
  journal={The FASEB Journal},
We hypothesized that exposure to hyperbaric oxygen (HBO2) would mobilize stem/progenitor cells from the bone marrow by a nitric oxide (.NO) dependent mechanism. The population of CD34+ cells in the peripheral circulation of humans (n=23) doubled in response to a single exposure to 2.0 atmospheres absolute (ATA) O2 for 2 hours. Over a course of twenty treatments, circulating CD34+ cells increased eightfold, although the over‐all circulating white cell count was not significantly increased. The… 

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