Stem cell mobilization by hyperbaric oxygen

@article{Thom2006StemCM,
  title={Stem cell mobilization by hyperbaric oxygen},
  author={Stephen Thom and Veena M. Bhopale and Omaida C Velazquez and Lee Joshua Goldstein and Lynne H. Thom and Donald G. Buerk},
  journal={The FASEB Journal},
  year={2006},
  volume={20}
}
We hypothesized that exposure to hyperbaric oxygen (HBO2) would mobilize stem/progenitor cells from the bone marrow by a nitric oxide (.NO) dependent mechanism. The population of CD34+ cells in the peripheral circulation of humans (n=23) doubled in response to a single exposure to 2.0 atmospheres absolute (ATA) O2 for 2 hours. Over a course of twenty treatments, circulating CD34+ cells increased eightfold, although the over‐all circulating white cell count was not significantly increased. The… 

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References

SHOWING 1-10 OF 42 REFERENCES
Mobilization of Endothelial Progenitor Cells in Patients With Acute Myocardial Infarction
TLDR
Flow cytometry revealed that circulating MNCCD34+ counts significantly increased in patients with acute myocardial infarction, peaking on day 7 after onset, whereas they were unchanged in control subjects who had no evidence of cardiac ischemia.
Characterization and quantitation of primitive hematopoietic progenitor cells present in peripheral blood autografts.
TLDR
Results suggest that peripheral blood mononuclear cells (PBMC) collected by leukapheresis following HD-CTX plus C-HGF mobilization contain not only differentiated HPC but also more primitive HPC.
Hyperbaric oxygen selectively induces angiopoietin-2 in human umbilical vein endothelial cells.
Exercise acutely increases circulating endothelial progenitor cells and monocyte-/macrophage-derived angiogenic cells.
Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells
TLDR
It is indicated that eNOS expressed by bone marrow stromal cells influences recruitment of stem and progenitor cells, which may contribute to impaired regeneration processes in ischemic heart disease patients, who are characterized by a reduced systemic NO bioactivity.
Effect of hyperoxia on vascular endothelial growth factor levels in a wound model.
TLDR
Hyperbaric oxygen therapy increases vascular endothelial growth factor (VEGF) levels in wounds and increased VEGF production seems to explain in part the angiogenic action of HBO.
Origin of endothelial progenitors in human postnatal bone marrow.
TLDR
Because MAPCs can be expanded in culture without obvious senescence for more than 80 population doublings, they may be an important source of endothelial cells for cellular pro- or anti-angiogenic therapies.
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
TLDR
It is shown that SDF-1 gene expression is regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1) in endothelial cells, resulting in selective in vivo expression of S DF-1 in ischemic tissue in direct proportion to reduced oxygen tension.
Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization
TLDR
Findings indicate that circulating EPCs are mobilized endogenously in response to tissue ischemia or exogenously by cytokine therapy and thereby augment neovascularization of ischemic tissues.
Synergistic Effect of Bone Marrow Mobilization and Vascular Endothelial Growth Factor-2 Gene Therapy in Myocardial Ischemia
TLDR
Mobilization of endothelial progenitor cells with cytokines potentiates VEGF-2 gene therapy for myocardial ischemia and enhances bone marrow cell incorporation into ischemic myocardium.
...
...