Stem cell maintenance in the adult mammalian hippocampus: a matter of signal integration?

@article{Schwarz2012StemCM,
  title={Stem cell maintenance in the adult mammalian hippocampus: a matter of signal integration?},
  author={Tobias Schwarz and Birgit Ebert and Dieter Chichung Lie},
  journal={Developmental neurobiology},
  year={2012},
  volume={72 7},
  pages={1006-15}
}
The continuous generation of new neurons from stem cells in the hippocampal dentate gyrus is considered an important contributor to hippocampal plasticity. A prerequisite for the life-long generation of new dentate granule neurons is the maintenance of the neural stem cell pool. A number of essential molecular regulators and signals for hippocampal neural stem cell maintenance have been identified, but how these pathways interact to prevent precocious differentiation or exhaustion of the stem… CONTINUE READING