Stem cell gene SALL4 suppresses transcription through recruitment of DNA methyltransferases.

@article{Yang2012StemCG,
  title={Stem cell gene SALL4 suppresses transcription through recruitment of DNA methyltransferases.},
  author={Jianchang Yang and Tyler R Corsello and Yupo Ma},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 3},
  pages={1996-2005}
}
The stem cell protein SALL4 plays a vital role in maintaining stem cell identity and governing stem cell self-renewal through transcriptional repression. To explore SALL4-mediated mechanisms involved in transcriptional repression, we investigated DNA modifications underlying its regulatory activities. By a luciferase activity assay, we found that both histone deacetylase inhibitor valproic acid (VPA) and DNA methylation inhibitor 5-azacytidine (5-azaC) specifically reversed the repression… CONTINUE READING

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