Stem cell factor stimulates the chemotaxis, integrin upregulation, and survival of human basophils.

@article{Heinemann2005StemCF,
  title={Stem cell factor stimulates the chemotaxis, integrin upregulation, and survival of human basophils.},
  author={Akos Heinemann and Gunter Johannes Sturm and Martina Ofner and Eva M Sturm and Charlotte Weller and Bernhard A. Peskar and Adele Hartnell},
  journal={The Journal of allergy and clinical immunology},
  year={2005},
  volume={116 4},
  pages={820-6}
}
BACKGROUND Little is known about the mechanisms that regulate the selective recruitment of basophils to sites of allergic inflammation. OBJECTIVE Here we examine the role of stem cell factor (SCF) in the regulation of basophil function. METHODS Human basophils were isolated from peripheral blood, and their migration was investigated in chemotaxis assays. Apoptosis was detected by means of annexin V and propidium iodide staining. The expression of cell-surface molecules was measured by means… CONTINUE READING

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