Stem cell factor enhances the survival but not the self-renewal of murine hematopoietic long-term repopulating cells.

@article{Li1994StemCF,
  title={Stem cell factor enhances the survival but not the self-renewal of murine hematopoietic long-term repopulating cells.},
  author={Chung Li and Gibbes R. Johnson},
  journal={Blood},
  year={1994},
  volume={84 2},
  pages={408-14}
}
The effects of stem cell factor (SCF) have been tested on a murine bone marrow subpopulation (RH123lo, Lin-, Ly6A/E+) that is highly enriched for long-term hematopoietic repopulating cells. SCF maintained cells from this population with long-term repopulating ability for up to 10 days in vitro. However, compared with freshly isolated cells, the level of engraftment in vivo by the cultured cells declined during the in vitro culture period, suggesting that SCF alone was unable to stimulate the… CONTINUE READING
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Muller-Sieburg CE: Maintenance of high levels of pluripotent hematopoietic stem cells in vitor: effect of stromal cells and c-kit

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