Stem cell factor and erythropoietin inhibit apoptosis of human erythroid progenitor cells through different signalling pathways.

@article{Sui2000StemCF,
  title={Stem cell factor and erythropoietin inhibit apoptosis of human erythroid progenitor cells through different signalling pathways.},
  author={Xingwei Sui and Sanford B. Krantz and Zhizhuang Joe Zhao},
  journal={British journal of haematology},
  year={2000},
  volume={110 1},
  pages={
          63-70
        }
}
Erythropoietin (EPO) and stem cell factor (SCF) are two important factors in human erythropoiesis. We have recently demonstrated that SCF and EPO synergistically activate mitogen-activated protein (MAP) kinase, thereby promoting growth of human erythroid colony-forming cells (ECFCs). In the present study, we have examined the intracellular mechanisms by which SCF and EPO maintain survival of these cells. In the absence of SCF and EPO, human ECFCs underwent rapid apoptosis. The process was… CONTINUE READING
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